The Undesirables is a comedy about a group of experimental test subjects living underground in an Above Top Secret government facility. It is much like a prison in the way that most of them are being held against their will, however, they remain docile with the promise that they will be let go after their various tests are complete.
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For the most part, the group is content to live in the facility, going to their specified rooms on mandatory testing days, although they were each abducted after having adverse reactions to secret prototype drug testing in the free world. Some of them are beginning to want to go home, back to their lives, after realizing they are being lied to and have been for a long time.
The comedy in the beginning of the series lies in the interactions between the different characters and the strange afflictions and side effects caused by the experiments being run on them. The Undesirables eventually find a way to use their freakish abilities to their advantage and escape the government compound so the facility sends amalgamated beast men and women, the Chimeras, to track down the Undesirable test subjects. This is where we see that the facility is not actually run by a human.
It is revealed the Undesirables were helping the facility to create new genetically modified human beings, each having a featured book in the anthology. The team the government sends consists of Nephilim (a fallen angel), Tor (a minotaur), Mongrel (a wolf woman), Medusa (a modified version of the original), and Griffin (the team’s mascot). The facility is shown to be run by a reptilian extra terrestrial who wants desperately to go home and needs the ancient astronaut’s technical knowledge to do so.
It is revealed that the Undesirables are the humans the facility’s geneticists use for practice. People the government can abduct and experiment on with no intention of ever sending them back to the lives they once knew. They have no chance at running away from or defeating the team sent after them. The only positive thing about their position is their head start on their adversaries… and the power that still lies dormant in some of them.